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4CMC


4CMC, also called 4-ChloroMethCathinone, is a novel Research Chemical from the substituted cathinone family. It is a strong dopamine and serotonine releaser without acting as reuptake inhibitor. It comes in large transparent crystals.

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Structure


The IUPAC of 4CMC is '1-(4-chlorophenyl)-2-(methylamino)propan-1-one', its CAS number is 2914790090.

Chemical structure of 4CMC

Legality


This product must be legal in the destination country or we wont accept the order. It is the customer's responsibility to conduct the necessary research regarding their local laws. Below you find a map that shows how we see the current situation regarding legality of 4cmc. Our own law-research came to the conclusion that 4cmc is unregulated in Netherlands, Spain, Romania, Liechtenstein, Slovakia, Portugal.
If you think this data is incorrect please email us about it providing law-texts. We only ship to green areas. We are sure 4cmc is banned in the red areas. We dont know about the grey/brown areas, if you want a shipment to such a country please provide us your local law-texts and we will will change color to green after a positive check.

legal info map for our product 4CMC, green are countries with no ban, red with ban, grey is unknown
Banned. We dont ship 4CMC there
Legal. We ship 4CMC there
Unknown. Mail us before you order

Product description


4CMC, also known as Clephedrone, is a stimulant drug of the cathinone class that has been sold online as a designer drug.

Pharmacodynamics

In radioligand binding assays, 4-CMC had very low affinities of 9,410 nM, 28,700 nM, and 19,600 nM for the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET), respectively. In uptake potency assays, 4-CMC had low uptake potencies of 208 nM, 670 nM, and 75.5nM for the DAT, SERT, and NET, respectively. 4-CMC possessed full efficacy at stimulating the release of dopamine. The maximal response elicited by 4-CMC was 83.5% of the efficacy of methamphetamine. The maximal response elicited by 4-CMC was 124% of the maximal efficacy of methamphetamine. 4-CMC was more potent (EC50value = 1,980 nM) at stimulating release of serotonin compared to methamphetamine (27,500 nM).

AnimalStudies

In mouse locomotor activity assays, treatment with 2.5 to 10 mg/kg 4-CMC i.p. resulted in time-and dose-dependent increases in locomotion. Peak locomotor effects were observed following 5 mg/kg 4-CMC. Maximal locomotor stimulant effects of 5 mg/kg 4-CMC occurred 10-40 min post injection and lasted 70-230 min. Compared to cocaine, methamphetamine, and MDMA, the maximal stimulant effectsof 4-CMC were 66%, 63% and 64%, respectively. In drug discrimination assays, 4-CMC i.p. fully substituted (ED50= 4.3mg/kg) for the discriminative stimulus effects of 10 mg/kg, i.p. cocaine in rats. 4-CMC also fully substituted (ED50= 3.9mg/kg) for the discriminative stimulus effects of 1.0mg/kg, i.p.(+)-methamphetamine.

Quality

We make 4CMC at our own lab. Crystals are trasparent and huge, see image below. It has a purity over 99%. Please store sealed. For long term storage keep at -20 degree. Durability is 7 years.

Image from our product 4CMC-crystals which we make at our dedicated lab

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